Bücher zu Vitamin K 2:
Aktuelle Forschungsergebnisse zu Vitamin K 2 – MK 4 und MK 7
Vitamin K 2 (insb. Super K von LEF Europe) darf bei gleichzeitiger Einnahme von Blutverdünnern wie z.B. Marcumar nur mit Zustimmung eines Arztes eingesetzt werden.
Arbeitsbuch Seite 471 ff:
K 2 Lectures:
Vitamin K2 Workshop – Part 1
Minute 33:30 ff.
Danach K 2 bei Neuropathien und Muskelkrämpfen
Vitamin K2 Workshop – Part 2 (Schurgers & Maresz)
Vitamin K 2 and Calcification – 1929 Vitamin K = Koagulationsfaktor
14 Vitamin K dependant Proteins werden carboxiliert
Warfarin als Vitamin KI Antagonist verhindert nicht die erste Karboxilierung, wohl aber den Recycling-Prozess von Vitamin K 1.
Warfarin verursacht Calcification. – Minute 12:00
Minute 15:00 -MGP – Matrix Gla Protein wird durch K 2 carboxiliert und verhindert Calcifacation.
Minute 18:00 – Calcification ist kein später Prozeß, sondern ein früher Prozeß beim Start der Plaques.
Minute 21:30 – K 2 – Mk 7 führt zur Rückbildung von Arterienverkalkung.
Affect on Heart Health: The body produces Matrix Gla Protein (MGP), a K-dependent protein that is the most potent natural inhibitor of calcification known today.1 But in order to perform this function, MGP needs to be activated. When the body has adequate Vitamin K2 (specifically as menaquinone-7, or MK-7, as it is the most biologically active and available form of Vitamin K2), MGP repels calcium from depositing in the arteries and blood vessels, returning it to the bloodstream so it can be utilized by other systems, such as building strong, dense bones.
Mechanism of Action: Vitamin K is not a single compound. It consists of a group of fat-soluble vitamins that are essential for the body to have normal coagulation activity, to utilize calcium for healthy bones, arteries and soft tissues. The vitamin K family is divided into vitamin K1 – one molecule (phylloquinone) and vitamin K2 – a group of molecules (menaquinones).
While both Vitamin K1 and Vitamin K2 are responsible for blood clotting, due to its molecular structure, it is Vitamin K2 that is available and can be utilized by soft tissues and systems beyond the liver.
K vitamins play an essential role as cofactor for the enzyme γ-glutamyl carboxylase, which is involved in carboxylation of the vitamin K-dependent proteins – specifically, the conversion of peptide-bound glutamic acid (Glu) to γ-carboxy glutamic acid (Gla).
Carboxylation, or activation, of vitamin K-dependent proteins (called Gla-proteins) serves as a recycling pathway to recover vitamin K from its epoxide metabolite (KO) for reuse in carboxylation. Several human Gla-containing proteins synthesized in several different types of tissues have been discovered. But specific to cardiovascular health, Matrix gla protein (MGP) is calcification inhibitory protein found in numerous body tissues, but its role is most pronounced in cartilage and in arterial vessel walls.
Vitamin K2 activates clotting factors, MGP and osteocalcin – proteins produced in the liver, bone and vasculature, which coagulate blood, “clean up” calcium deposits stored in the arteries and bind it to the surface of bone. The activation occurs via carboxylation reaction, in which vitamin K acts as a cofactor for gammaglutamyl carboxylase – an enzyme transforming proteins’ Glu residues into Gla, which gives them an ability to bind calcium ions. Then Vitamin K2 is being recycled, which allows the body to reuse it.
K2 in Media
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